Amenhotep II first Son died

“also when they shall be afraid of that which is high, and fears shall be in the way, and the almond tree shall flourish, and the grasshopper shall be a burden, and desire shall fail: because man goeth to his long home, and the mourners go about the streets: or ever the silver cord be loosed, or the golden bowl be broken, or the pitcher be broken at the fountain, or the wheel broken at the cistern. Then shall the dust return to the earth as it was: and the spirit shall return unto God who gave it.”

‭‭Ecclesiastes‬ ‭12‬:‭5‬-‭7‬ ‭KJV‬‬

https://bible.com/bible/1/ecc.12.7.KJV 

Thutmose IV was 

not fatherless; he was the son of Pharaoh Amenhotep II and Queen Tiaa. 

However, Thutmose IV was likely not the original, intended heir to the throne. He was not the crown prince, and his ascension to the throne was unexpected, leading to speculation that he may have bypassed older brothers to take power. 

Key Details Regarding His Ascension:

• "Dream Stele" Propaganda: Thutmose IV erected a tablet (the Dream Stele) between the paws of the Great Sphinx to justify his unexpected kingship. The text claims the Sphinx promised him the throne if he cleared the sand from around it, suggesting a need to legitimize his rule, perhaps because he was not the rightful heir.
• Disappearance of Heirs: Scholars believe that internal turmoil, such as the sudden death or disappearance of his older brothers, allowed Thutmose IV to ascend.
• Mother's Status: His mother, Tiaa, was not the primary wife of Amenhotep II during his lifetime, but was elevated to "Great Royal Wife" only after Thutmose IV became king. 

Thutmose IV ruled as the 8th Pharaoh of the 18th Dynasty (approx. 1401–1391 BC) and was the father of Amenhotep III. 

His father

The exact cause of 

Amenhotep II's death around 1400 BCE, at about age 45, is unknown, as his mummy showed no clear signs of disease or injury, though he had good teeth and was a strong, athletic pharaoh. His death led to his son, Thutmose IV, succeeding him in a relatively peaceful reign in the Valley of the Kings. 

Key Details:

• Age at Death: Approximately 45 years old.
• Mummy Examination: Revealed good health and teeth, with no evidence of foul play or major illness.
• Reign: He ruled for around 26 years, maintaining peace and strong alliances.
• Burial: Interred in his tomb (KV35) in the Valley of the Kings. 

While some pharaohs died from dental issues, there's no specific infection linked to Amenhotep II's passing; it remains one of ancient history's mysteries.